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Tocris Bioscience(优势品牌)
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当前位置: 首页 > 产品中心 > kinase > Tocris/4640/5610毫克
商品详细Tocris/4640/5610毫克
Tocris/4640/5610毫克
Tocris/4640/5610毫克
商品编号: 5640/10
品牌: Tocris Bioscience
市场价: ¥3100.00
美元价: 1860.00
产地: 美国(厂家直采)
公司:
产品分类: 激酶
公司分类: kinase
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:HighaffinityandselectiveALKandROS1inhibitor
AlternativeNames:Lorlatinib
ChemicalName:(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxADIazacyclotetradecine-3-carbonitrile
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectiveALKandROS1inhibitor(Kivaluesare<0.02,<0.07and0.7nMforROS1,wild-typeALKandALK-L1196M,respectively).Exhibits>100-foldselectivityforROS1overapanelof204otherkinases.InhibitsproliferationofBaF3cellscontainingcrizotinib-resistantROS1mutationinvitro.Inhibitstumorgrowthinrelevantmousemodels.Orallyavailableandbrainpenetrant.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

CompoundLibraries

PF06463922isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt406.41
FormulaC21H19FN6O2
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1454846-35-5
PubChemID71731823
InChIKeyIIXWYSCJSQVBQM-LLVKDONJSA-N
SmilesC[C@@H](O3)C4=C(C=CC(F)=C4)C(N(C)CC1=NN(C)C(C#N)=C1C2=CC3=C(N)N=C2)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.64100
ethanol40.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight406.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.46mL12.3mL24.61mL
5mM0.49mL2.46mL4.92mL
10mM0.25mL1.23mL2.46mL
50mM0.05mL0.25mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet