Biological Activity
Potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 361.37 |
| Formula | C18H20FN3O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1817626-54-2 |
| Smiles | CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.14 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 361.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.67 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.53 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Lee et al (2017) Discovery of clinical candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a potent, selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) J.Med.Chem. 60 6621 PMID: 28498658
Keywords: PF 06650833, supplier, PF06650833, IRAK4, Interleukin-1, receptor-associated, kinases, potent, selective, orally, bioavailable, IRAK, Cytokines, IRAK, Tocris Bioscience
