BiologicalActivity
Selectivecaseinkinase1εinhibitor;displays22-foldgreaterpotencytowardsCK1εthanCK1δ(IC50valuesare32and711nMforCK1εandCK1δrespectively).ATPcompetitive.DisplaysminimaleffectonthecircADIanclock.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofPF4800567isreviewedonthechemicalprobeswebsite.
CompoundLibraries
PF4800567hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 396.27 |
| Formula | C17H18ClN5O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1391052-28-0 |
| PubChemID | 71751553 |
| InChIKey | QZXZQMUZEHTFHD-UHFFFAOYSA-N |
| Smiles | NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.63 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight396.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.62mL | 25.24mL |
| 5mM | 0.5mL | 2.52mL | 5.05mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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ProductDatasheets
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