Tocris/PF 543 hydrochloride/5754/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 543 hydrochloride/5754/10/10 mg

Tocris/PF 543 hydrochloride/5754/10/10 mg

商品编号： 5754/10

品牌： Tocris Bioscience

市场价： ¥3700.00

美元价： 2220.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveSphK1inhibitor

ChemicalName:(2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanolhydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveSphK1inhibitor(IC₅₀=2nM;K_i=3.6nM).Exhibits>100-foldselectivityforSphk1overSphk2.Alsoexhibits>5,000foldselectivityoverS1P_1-5receptorsand48proteinandlipidkinases.Attenuatesproliferationandinducesnecrosisinhumancolorectalcancercellsinvitro.SuppressesHCT-116tumorxenograftgrowthinmice.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	502.07
Formula	C₂₇H₃₁NO₄S.HCl
Storage	DesiccateatRT
Purity	≥98%(HPLC)
CASNumber	1706522-79-3
PubChemID	121230770
InChIKey	WNKWAZFYPZMDGJ-VQIWEWKSSA-N
Smiles	CC1=CC(OCC2=CC=C(CN3CCC[C@@H]3CO)C=C2)=CC(CS(C4=CC=CC=C4)(=O)=O)=C1.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	50.21	100
	ethanol	10.04	20
	water	5.02	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight502.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.99mL	9.96mL	19.92mL
5mM	0.4mL	1.99mL	3.98mL
10mM	0.2mL	1mL	1.99mL
50mM	0.04mL	0.2mL	0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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TechnicalData

SolubilityData

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