BiologicalActivity
Potentandselectiveinhibitoroffocaladhesionkinase(FAK)(IC50=4nM).Displays50-250-foldselectivityforFAKoverotherproteinkinases.Blocksserumandfibronectin-directedmigrationanddecreasesfocaladhesionturnoverinvitro.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PF573228isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 491.49 |
| Formula | C22H20F3N5O3S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 869288-64-2 |
| PubChemID | 11612883 |
| InChIKey | HESLKTSGTIBHJU-UHFFFAOYSA-N |
| Smiles | O=C(N3)CCC1=C3C=CC(NC2=NC(NCC4=CC=CC(S(=O)(C)=O)=C4)=C(C(F)(F)F)C=N2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight491.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.17mL | 20.35mL |
| 5mM | 0.41mL | 2.03mL | 4.07mL |
| 10mM | 0.2mL | 1.02mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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