Tocris/PF 6274484/5939/50/50毫克-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/PF 6274484/5939/50/50毫克

Tocris/PF 6274484/5939/50/50毫克

商品编号： 5939/50

品牌： Tocris Bioscience

市场价： ¥15300.00

美元价： 9180.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:HighaffinityandpotentcovalentEGFRkinaseinhibitor

ChemicalName:N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandpotentcovalentEGFRkinaseinhibitor(K_i=0.14nM).InhibitsautophosphorylationofWTandmutantEGFRintumorcells(IC₅₀valuesare5.8and6.6nM,respectively).

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc.

TechnicalData

M.Wt	372.78
Formula	C₁₈H₁₄ClFN₄O₂
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1035638-91-5
PubChemID	74766099
InChIKey	TUYDDIWQXWTNSW-UHFFFAOYSA-N
Smiles	COC1=CC2=C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)C=C1NC(C=C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	37.28	100
	ethanol	3.73	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight372.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.68mL	13.41mL	26.83mL
5mM	0.54mL	2.68mL	5.37mL
10mM	0.27mL	1.34mL	2.68mL
50mM	0.05mL	0.27mL	0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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