BiologicalActivity
Potentandselectivecaseinkinase1ε(CK1ε)andCK1δinhibitor(IC50valuesare7.7and14nMrespectively)thatdisplays>30-foldselectivityover42othercommonkinases.InhibitsPERproteinnucleartranslocation(EC50=290nM)causingphaseshiftsincircADIanrhythmsandattenuatesmethamphetamine-stimulatedlocomotioninvivo.
CompoundLibraries
PF670462isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 410.32 |
| Formula | C19H20FN5.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 950912-80-8 |
| PubChemID | 51049607 |
| InChIKey | PSNKGVAXBSAHCH-UHFFFAOYSA-N |
| Smiles | NC1=NC=CC(C2=C(C4=CC=C(F)C=C4)N=CN2C3CCCCC3)=N1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.03 | 100 | |
| ethanol | 20.52 | 50 | |
| water | 41.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight410.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.19mL | 24.37mL |
| 5mM | 0.49mL | 2.44mL | 4.87mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
MolarityCalculator
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ProductDatasheets
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