Biological Activity
MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.
Technical Data
| M. Wt | 293.4 |
| Formula | C14H15NO2S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1558598-41-6 |
| PubChem ID | 2145809 |
| InChI Key | GPURHDUTZUYAFI-GHXNOFRVSA-N |
| Smiles | CC(CN1C(S/C(C1=O)=CC2=CC=C(C=C2)O)=S)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.34 | 100 | |
| ethanol | 29.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 293.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.41 mL | 17.04 mL | 34.08 mL |
| 5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
| 10 mM | 0.34 mL | 1.7 mL | 3.41 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Shibata et al (2014) DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol.Cell 53 7 PMID: 24316220
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