Biological Activity
Selective hMC3 receptor antagonist (IC50 = 210 nM). Exhibits no activity at hMC4 receptors and hMC5 receptors.
Technical Data
| M. Wt | 1008.19 |
| Formula | C51H69N13O9 |
| Sequence |
XDXXRWK (Modifications: X-1 = Ac-Nle, X-3 = beta-Ala, X-4 = D-2-Nal, Lys-7 = C-terminal amide, Asp-2, Lys-7, Cyclized) |
| Storage | Store at -20°C |
| CAS Number | 944111-22-2 |
| PubChem ID | 90488990 |
| InChI Key | ZFZDDBJAFMOQSH-JHMPFZGISA-N |
| Smiles | [H]N([C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC3=CC=CC=C3C=C2)NC(=O)CCNC1=O)C(N)=O)C(=O)C(CCCC)NC(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 25% ethanol / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1008.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.99 mL | 4.96 mL | 9.92 mL |
| 5 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 10 mM | 0.1 mL | 0.5 mL | 0.99 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Grieco et al (2007) Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28 1191 PMID: 17482720
Keywords: PG 106, supplier, PG106, MC3, melanocortin, receptors, antagonists, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
