BiologicalActivity
DualAktandPDK1inhibitor;bindsthepleckstrinhomology(PH)domainofAktandPDK1(Kivaluesare2.7and5.2μM,respectively).InhibitsAktphosphorylationandAktdownstreamtargets;alsoinducesapoptosisinvitro.Displayssynergisticantitumoreffectwhencombinedwithchemotherapeuticsinbreastcancermousemodels.
CompoundLibraries
PHT427isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 409.61 |
| Formula | C20H31N3O2S2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1191951-57-1 |
| PubChemID | 44240850 |
| InChIKey | BYWWNRBKPCPJMG-UHFFFAOYSA-N |
| Smiles | O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.96 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight409.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.44mL | 12.21mL | 24.41mL |
| 5mM | 0.49mL | 2.44mL | 4.88mL |
| 10mM | 0.24mL | 1.22mL | 2.44mL |
| 50mM | 0.05mL | 0.24mL | 0.49mL |
MolarityCalculator
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ProductDatasheets
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