Biological Activity
Potent Pim-1 kinase inhibitor (Ki = 91 nM).
Compound Libraries
PIM-1 Inhibitor 2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 322.75 |
| Formula | C17H11ClN4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 477845-12-8 |
| PubChem ID | 2765355 |
| InChI Key | AQVFETGXIRKVAQ-UHFFFAOYSA-N |
| Smiles | NC1=NC=CC(C3=CC2=C(C4=CC=C(Cl)C=C4)ON=C2C=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.21 | 75 |
Preparing Stock Solutions
The following data is based on the product molecular weight 322.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.1 mL | 15.49 mL | 30.98 mL |
| 5 mM | 0.62 mL | 3.1 mL | 6.2 mL |
| 10 mM | 0.31 mL | 1.55 mL | 3.1 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Pierce et al (2008) Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. J.Med.Chem. 51 1972 PMID: 18290603
Keywords: PIM-1 Inhibitor 2, supplier, Pim-1, kinase, inhibitors, inhibits, kinases, PIM-1, Inhibitor2, Pim, Kinase, Pim, Kinase, Tocris Bioscience
