BiologicalActivity
Potentinhibitorofpoly(ADP-ribose)polymerase(PARP)(EC50=20nM).~1000-foldmorepotentthan3-Aminobenzamide(Cat.No.0788).Protectsprimaryneuronalcellsfromoxygen-glucosedeprivationinvitroandreducesinfarctsizefollowingfocalcerebralischemiainvivo.Displaysprotectiveeffectsagainstcisplatin-inducedkidneyinjury.AlsodisplaysactivityatPim-1andPim-2kinasesathigherconcentrations(IC50valuesare3.7and16μMrespectively).
CompoundLibraries
PJ34hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 331.8 |
| Formula | C17H17N3O2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 344458-15-7 |
| PubChemID | 16760621 |
| InChIKey | RURAZZMDMNRXMI-UHFFFAOYSA-N |
| Smiles | Cl.CN(C)CC(=O)NC1=CC2=C(NC(=O)C3=CC=CC=C23)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.18 | 100 | |
| water | 33.18 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight331.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.01mL | 15.07mL | 30.14mL |
| 5mM | 0.6mL | 3.01mL | 6.03mL |
| 10mM | 0.3mL | 1.51mL | 3.01mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |
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ProductDatasheets
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