Biological Activity
Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.
Compound Libraries
PK-THPP is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 468.59 |
Formula | C29H32N4O2 |
Storage | Store at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 1332454-07-5 |
PubChem ID | 53464059 |
InChI Key | CJZGRIRZVHNUSM-UHFFFAOYSA-N |
Smiles | O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N(C3)CCC4=C3C(N5CCC(C(CCC)=O)CC5)=NC=N4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
1eq. HCl | 9.37 | 20mM with gentle warming | |
DMSO | 23.43 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 468.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
10 mM | 0.21 mL | 1.07 mL | 2.13 mL |
50 mM | 0.04 mL | 0.21 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cotten (2013) TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 116 810 PMID: 23460565
Coburn et al (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 7 123 PMID: 21916012
Keywords: PK-THPP, supplier, potent, TASK3, channels, blockers, TWIK, related, acid, sensitive, K+, two, pore, potassium, potassium, K2P9.1, subfamily, member, 9, Two-P, Potassium, Channels, Two-P, Potassium, Channels, Tocris Bioscience