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当前位置: 首页 > 产品中心 > kinase > Tocris/PLX 647二氢氯化物/5102/10/10 mg
商品详细Tocris/PLX 647二氢氯化物/5102/10/10 mg
Tocris/PLX 647二氢氯化物/5102/10/10 mg
Tocris/PLX 647二氢氯化物/5102/10/10 mg
商品编号: 5102/10
品牌: Tocris Bioscience
市场价: ¥3980.00
美元价: 2388.00
产地: 美国(厂家直采)
公司:
产品分类: 激酶
公司分类: kinase
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:PotentdualFms/KITinhibitor
ChemicalName:5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinaminedihydrochloride
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentdualKIT/Fmsinhibitor(IC50valuesare16and28nMrespectively).InhibitsBCR-FMScellproliferationandosteoclastdifferentiationinvitro(IC50valuesare92and170nMrespectively).AttenuatesLPS-inducedTNFαandIL-6release,mastcellactivationandmacrophagekidneyproliferationinvivo.

CompoundLibraries

PLX647dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt455.3
FormulaC21H17F3N4.2HCl
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber1779796-38-1
PubChemID78243730
InChIKeyMVMKWLRKACAUTB-UHFFFAOYSA-N
SmilesFC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO45.53100
ethanol45.53100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight455.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.2mL10.98mL21.96mL
5mM0.44mL2.2mL4.39mL
10mM0.22mL1.1mL2.2mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet