Biological Activity
Competitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NR2A, NR2B, NR2C and NR2D subunit-containing receptors respectively. Selective over AMPA receptors.
Technical Data
| M. Wt | 224.15 |
| Formula | C6H13N2O5P |
| Storage | Store at +4°C |
| CAS Number | 113919-36-1 |
| PubChem ID | 17756792 |
| InChI Key | ILRBBHJXTYIHTP-UHFFFAOYSA-N |
| Smiles | OP(CN1CC(C(O)=O)NCC1)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 224.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.46 mL | 22.31 mL | 44.61 mL |
| 5 mM | 0.89 mL | 4.46 mL | 8.92 mL |
| 10 mM | 0.45 mL | 2.23 mL | 4.46 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.89 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Harris and Davies (1992) Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7. Brain Res. 594 176 PMID: 1361408
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
Keywords: PMPA (NMDA antagonist), supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, PMPC, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
