Biological Activity
Highly selective dopamine D3 receptor antagonist. Induces phospholipidosis and exhibits antischizophrenic activity in vivo.
Compound Libraries
PNU 177864 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 438.89 |
| Formula | C18H21F3N2O3S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 250266-51-4 |
| PubChem ID | 56972219 |
| InChI Key | UOMDLHQTLPWCCE-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(OC(F)(F)F)C=C1)(NC2=CC=C(CCNCCC)C=C2)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.89 | 100 | |
| water | 8.78 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 438.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.28 mL | 11.39 mL | 22.78 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.28 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Vonderfecht et al (2004) Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence. Toxicol.Pathol. 32 318 PMID: 15204973
Rudmann et al (2004) Epididymal and systemic phospholipidosis in rats and dogs treated with dopamine D3 selective antagonist PNU-177864. Toxicol.Pathol. 32 326 PMID: 15204974
Keywords: PNU 177864 hydrochloride, supplier, selective, D3, antagonists, Dopamine, Receptors, dopaminergic, PNU177864, hydrochloride, D3, Receptors, D3, Receptors, Tocris Bioscience
