Biological Activity
P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS (Cat. No. 0625).
Technical Data
| M. Wt | 599.3 |
| Formula | C14H10N3Na4O12PS2 |
| Storage | Desiccate at -20°C |
| CAS Number | 207572-67-6 |
| PubChem ID | 5132514 |
| InChI Key | LOTSPVPQHAUHCE-UHFFFAOYSA-N |
| Smiles | [Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(N=NC2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.93 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699
Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268
Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652
Keywords: iso-PPADS tetrasodium salt, supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, P2X, Receptors, P2X, Receptors, Tocris Bioscience
