Biological Activity
Competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively).
Technical Data
| M. Wt | 251.22 |
| Formula | C9H18NO5P |
| Storage | Desiccate at RT |
| CAS Number | 113190-92-4 |
| PubChem ID | 90488757 |
| InChI Key | GPFGYOMXVORLFH-RXZNUWRWSA-N |
| Smiles | O=P(CCC[C@@H]1C[C@H]([C@](O)=O)NCC1)(O)O.O=C([C@H]2NCC[C@@H](CCCP(O)(O)=O)C2)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 25.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 251.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.9 mL | 39.81 mL |
| 5 mM | 0.8 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Benveniste and Mayer (1992) Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists. Mol.Pharmacol. 42 679 PMID: 1435743
Feng et al (2005) The effect of competitive antagonist chain length on NMDA receptor subunit selectivity. Neuropharmacology 48 354 PMID: 15721167
Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066 PMID: 15743930
Keywords: PPPA, supplier, Competitive, NR2A, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, LY257883, LY, 257883, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
