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商品详细Tocris/PPTN盐酸盐/4862/10/10 mg

Tocris/PPTN盐酸盐/4862/10/10 mg

商品编号： 4862/10

品牌： Tocris Bioscience

市场价： ¥4700.00

美元价： 2820.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description: High affinity and selective P2Y₁₄ antagonist

Chemical Name: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride

Purity: ≥98% (HPLC)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

High affinity and selective P2Y₁₄ antagonist (K_B = 434 pM). Exhibits >10,000-fold selectivity for P2Y₁₄ over other P2Y receptors. Inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo. Also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

Technical Data

M. Wt	511.96
Formula	C₂₉H₂₄F₃NO₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	121513852
InChI Key	FKMVYPCBLWYNAV-UHFFFAOYSA-N
Smiles	FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.2	100
	ethanol	10.24	20

Preparing Stock Solutions

The following data is based on the product molecular weight 511.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.77 mL	19.53 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
10 mM	0.2 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.2 mL	0.39 mL

Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Gao et al (2013) The role of P2Y₁₄ and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 9 31 PMID: 22825617

Alsaqati et al (2014) Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol. 171 701 PMID: 24138077

Barrett et al (2013) A selective high-affinity antagonist of the P2Y₁₄ receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol. 84 41 PMID: 23592514

Keywords: PPTN hydrochloride, supplier, 1160271-30-6, high, affinity, selective, P2Y14, purinergics, antagonists, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience

品牌介绍

Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。 Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。 Tocris Bioscience的主要产品包括： Small Molecules Peptides Aptamers Controlled Substances Compound Libraries DREADD Ligands Fluorescent Imaging Ligand Sets Optopharmacology Reagents Toxins 按照研究领域细分： Cancer Cardiovascular System Endocrinology Immunology Neuroscience Pain & Inflammation Respiratory System

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