Biological Activity
Potent and selective P2Y6 receptor agonist (EC50 values are 70, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively). Induces contractions of rat isolated intrapulmonary arteries in vitro.
Technical Data
| M. Wt | 566.26 |
| Formula | C17H18N2Na2O13P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 917567-60-3 |
| PubChem ID | 54591398 |
| InChI Key | LEICCBKKYICWFH-BWBFMJMBSA-L |
| Smiles | [Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N1C=CC(=O)N(CC(=O)C2=CC=CC=C2)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Preparing Stock Solutions
The following data is based on the product molecular weight 566.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.83 mL | 17.66 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.53 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
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References
References are publications that support the products' biological activity.
El-Tayeb et al (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4 and P2Y6 receptors. J.Med.Chem. 49 7076 PMID: 17125260
Mitchell et al (2012) Identification of contractile P2Y1, P2Y6, and P2Y12 receptors in rat intrapulmonary artery using selective ligands. J.Pharmacol.Exp.Ther. 343 755 PMID: 22991416
Keywords: PSB 0474, supplier, Potent, selective, P2Y6, agonists, Receptors, Purinergic, purinoceptors, PSB0474, 3-Phenacyl, UDP, disodium, salt, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
