Biological Activity
Highly potent P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.
Licensing Information
Sold with the permission of the University of Bonn.
Technical Data
| M. Wt | 609.54 |
| Formula | C26H17N3Na2O8S2 |
| Storage | Desiccate at RT |
| Purity | ≥95% (HPLC) |
| CAS Number | 1052087-90-7 |
| PubChem ID | 44583582 |
| InChI Key | QBLLYXXXOJUNCV-UHFFFAOYSA-L |
| Smiles | [Na+].[Na+].NC1=C(C=C(NC2=CC(=C(NC3=CC=CC=C3)C=C2)S([O-])(=O)=O)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.24 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 609.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.64 mL | 8.2 mL | 16.41 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 10 mM | 0.16 mL | 0.82 mL | 1.64 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hoffmann et al (2009) Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. J.Pharmacol.Exp.Ther. 331 648 PMID: 19690189
Baqi et al (2009) High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors. J.Med.Chem. 52 3784 PMID: 19463000
Felix et al (2011) Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinerg.Sig. 8 101 PMID: 22052555
Keywords: PSB 0739, supplier, PSB0739, potent, selective, p2y12, purine, receptors, antagonist, purinoceptors, purinergic, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
