Biological Activity
Potent and selective A1 adenosine receptor antagonist. Displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Demonstrates greater selectivity than DPCPX (Cat. No. 0439).
Compound Libraries
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Technical Data
M. Wt | 386.49 |
Formula | C21H30N4O3 |
Storage | Desiccate at +4°C |
Purity | ≥99% (HPLC) |
CAS Number | 524944-72-7 |
PubChem ID | 11689583 |
InChI Key | CIBIXJYFYPFMTN-UHFFFAOYSA-N |
Smiles | CCCCN1C(=O)N(CCCO)C2=C(NC(=N2)C23CC4CC2CC(C3)C4)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.65 | 100 | |
ethanol | 38.65 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 386.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.59 mL | 12.94 mL | 25.87 mL |
5 mM | 0.52 mL | 2.59 mL | 5.17 mL |
10 mM | 0.26 mL | 1.29 mL | 2.59 mL |
50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Abo-Salem et al (2004) Antinociceptive effects of novel A2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther 308 358 PMID: 14563788
Weyler et al (2006) Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones. Chem.Med.Chem. 1 891 PMID:
Keywords: PSB 36, supplier, Potent, selective, A1, antagonists, Receptors, adenosines, PSB36, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience