Biological Activity
CB1 receptor negative allosteric modulator (IC50 values are 45 and 209 nM for the inhibition of CP 55,940 and WIN 55,212-2 respectively). Has no effect at the CB2 receptor. Decreases food intake and body weight in rats.
Compound Libraries
PSNCBAM-1 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 392.88 |
| Formula | C22H21ClN4O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 877202-74-9 |
| PubChem ID | 11560249 |
| InChI Key | HDAYFSFWIPRJSO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.29 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.73 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Horswill et al (2007) PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br.J.Pharmacol. 152 805 PMID: 17592509
German et al (2014) Diarylureas as allosteric modulators of the cannabinoid CB1 receptor: structure-activity relationship studies on 1-(4-chlorophenyl)-3-{3-[6-(pyrrolidin-1-yl)pyridin-2-yl]phenyl}urea (PSNCBAM-1). J.Med.Chem. 57 7758 PMID: 25162172
Keywords: PSNCBAM-1, supplier, subtype, selective, cb1, cannabinoids, receptors, negative, allosteric, modulators, antagonists, hypophagic, CB1, Receptors, CB1, Receptors, Tocris Bioscience
