Biological Activity
Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).
Technical Data
| M. Wt | 292.36 |
| Formula | C16H12N4S |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 313984-77-9 |
| PubChem ID | 720937 |
| InChI Key | BGMSTNYJYPSLHN-UHFFFAOYSA-N |
| Smiles | C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 292.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.1 mL | 34.2 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Trattnig et al (2012) Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J.Biol.Chem. 287 25241 PMID: 22589534
Keywords: PU 02, supplier, PU02, negative, allosteric, modulators, NAMs, 5-HT3, receptors, serotonergics, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience
