Biological Activity
Atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT2A receptors (Ki = 0.4 nM for cloned human 5-HT2A receptors). Also displays nanomolar affinity for human D2 receptors.
Technical Data
| M. Wt | 426.48 |
| Formula | C23H27FN4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 144598-75-4 |
| PubChem ID | 115237 |
| InChI Key | PMXMIIMHBWHSKN-UHFFFAOYSA-N |
| Smiles | FC1=CC2=C(C(C3CCN(CCC4=C(C)N=C(C(O)CCC5)N5C4=O)CC3)=NO2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.26 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 426.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
| 10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Schotte et al (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology 124 57 PMID: 8935801
Dremencov et al (2007) Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology 194 63 PMID: 17530476
Megens and Awouters et al (1994) In vivo pharmacological profile of 9-hydroxyrisperidone, the major metabolite of the novel antipsychotic risperidone. 33 399 PMID:
Leysen et al (1994) Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. J.Clin.Psychiatry 55 5 PMID: 7520908
Keywords: Paliperidone, supplier, atypical, antipsychotic, 5-ht2a, serotonergic, serotonin, antagonists, dopamine, dopaminergic, d2, high, affinity, 9-OH-risperidone, 9-hydroxyrisperidone, 9-Hydroxyrisperidone, 9-OH-risperidone, 5-HT2A, Receptors, D2, Receptors, 5-HT2A, Receptors, Tocris Bioscience
