Biological Activity
Endogenous lipid that acts as a selective GPR55 agonist (EC50 values are 4, 19 800 and > 30 000 nM at GPR55, CB2 and CB1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo. Directly activates PPARα (EC50 = 3 μM) producing robust anti-inflammatory actions.
Technical Data
| M. Wt | 299.5 |
| Formula | C18H37NO2 |
| Storage | Store at RT |
| CAS Number | 544-31-0 |
| PubChem ID | 4671 |
| InChI Key | HXYVTAGFYLMHSO-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCCCCCCCCCC)NCCO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.99 | 20 | |
| ethanol | 7.49 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 299.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.34 mL | 16.69 mL | 33.39 mL |
| 5 mM | 0.67 mL | 3.34 mL | 6.68 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Lambert et al (2001) Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia 42 321 PMID: 11442148
Lambert et al (2002) The palmitoylethanolamide family: a new class of anti-inflammatory agents? Curr.Med.Chem. 9 663 PMID: 11945130
Lo Verme et al (2005) The search for the palmitoylethanolamide receptor. Life Sci. 77 1685 PMID: 15963531
Re et al (2005) Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet.J. 173 21 PMID: 16324856
Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302
Keywords: Palmitoylethanolamide, supplier, Endogenous, lipid, PPARα, PPARalpha, agonists, activity, Selective, GPR55, FAAH, PAA, PEA-preferring, acid, amidase, Peroxisome, Proliferator-activating, Receptors, PPAR, Cannabinoid, Anandamide, Fatty, Acid, Amide, Hydrolases, PEA, GPR55, PPARalpha, Receptors, Fatty, Acid, Amide, Hydrolase, (FAAH), Other, Cannabinoids, GPR55, Tocris Bioscience
