Biological Activity
The active principle of feverfew (Chrysanthemum parthenium). Antisecretory, anti-inflammatory and spasmolytic; inhibits the release of 5-HT from blood platelets. Also inhibits activation of NF-κB, and generation of leukotriene B4 and thromboxane B2.
Compound Libraries
Parthenolide is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 248.32 |
Formula | C15H20O3 |
Storage | Desiccate at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 20554-84-1 |
PubChem ID | 6473881 |
InChI Key | KTEXNACQROZXEV-SLXBATTESA-N |
Smiles | C/C1=CCC[C@]2(C)[C@@H](O2)[C@@H](OC([C@]3=C)=O)[C@H]3CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 12.42 | 100 | |
ethanol | 24.83 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 4.03 mL | 20.14 mL | 40.27 mL |
5 mM | 0.81 mL | 4.03 mL | 8.05 mL |
10 mM | 0.4 mL | 2.01 mL | 4.03 mL |
50 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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References
References are publications that support the products' biological activity.
Groenewegen and Heptinstall (1990) A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in vitro. J.Pharm.Pharmacol. 42 553 PMID: 1981582
Heptinstall et al (1986) Compounds extracted from feverfew that have anti-secretory activity contain an α-methylene butyrolactone unit. J.Pharm.Pharmacol. 38 709 PMID: 2877077
Sumner et al (1992) Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem.Pharmacol. 43 2313 PMID: 1319159
Hehner et al (1998) Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J.Biol.Chem. 273 1288 PMID: 9430659
Keywords: Parthenolide, supplier, 5-HT, release, inhibitors, inhibits, Serotonin, 5-Hydroxytryptamine, Receptors, 5-HT3, feverfew, 5-HT-Related, 5-HT3, Receptors, NF-kB/IkB, 5-HT-Related, Tocris Bioscience