Biological Activity
Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist.
Technical Data
| M. Wt | 592.68 |
| Formula | C19H24N4O2.2C2H6O4S |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 140-64-7 |
| PubChem ID | 8813 |
| InChI Key | YBVNFKZSMZGRAD-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCCCCCOC2=CC=C(C(N)=N)C=C2)C=C1)=N.OCCS(=O)(O)=O.OCCS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 592.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.69 mL | 8.44 mL | 16.87 mL |
| 5 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 10 mM | 0.17 mL | 0.84 mL | 1.69 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.34 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J.Neurosci. 12 970 PMID: 1532027
Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299 PMID: 7542607
Keywords: Pentamidine isethionate, supplier, Antimicrobial, inhibits, inhibitors, constitutive, nNOS, NMDA, antagonist, receptors, Nitric, Oxide, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Neuronal, oxide, Synthases, NMDA, Receptors, nNOS, Miscellaneous, Compounds, NMDA, Receptors, Tocris Bioscience
