Biological Activity
CNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.
Technical Data
| M. Wt | 138.17 |
| Formula | C6H10N4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 54-95-5 |
| PubChem ID | 5917 |
| InChI Key | CWRVKFFCRWGWCS-UHFFFAOYSA-N |
| Smiles | C1CCN2N=NN=C2CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.81 | 100 | |
| water | 13.81 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 138.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.24 mL | 36.19 mL | 72.37 mL |
| 5 mM | 1.45 mL | 7.24 mL | 14.47 mL |
| 10 mM | 0.72 mL | 3.62 mL | 7.24 mL |
| 50 mM | 0.14 mL | 0.72 mL | 1.45 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Rocha et al (1996) Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 26 105 PMID: 8985692
Walsh et al (1999) Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density. J.Pharmacol.Exp.Ther. 289 1626 PMID: 10336561
Dhir et al (2006) Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action. Prog.Neuro-Psychopharm.Biol.Psychiat. 30 1478 PMID:
Keywords: Pentylenetetrazole, supplier, CNS, stimulant, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, GABAB, GABAA, GABAC, PTZ, Miscellaneous, GABA, Miscellaneous, Glutamate, GABAB, Receptors, Miscellaneous, GABA, Tocris Bioscience
