Biological Activity
PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases Kv2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.
Technical Data
| M. Wt | 461.66 |
| Formula | C25H52NO4P |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 157716-52-4 |
| PubChem ID | 148177 |
| InChI Key | SZFPYBIJACMNJV-UHFFFAOYSA-N |
| Smiles | CCCCCCCCCCCCCCCCCCOP([O-])(OC1CC[N+](C)(CC1)C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 46.17 | 100 | |
| water | 46.17 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 461.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.17 mL | 10.83 mL | 21.66 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.33 mL |
| 10 mM | 0.22 mL | 1.08 mL | 2.17 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.43 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Delgado-Ramírez et al (2016) Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine. Pharmacol Rep. 68 457 PMID: 26922553
Fu et al (2009) Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res. 69 8967 PMID: 19920197
Tazzari et al (2008) Synergistic proapoptotic activity of recombinant TRAIL plus the Akt inhibitor Perifosine in acute myelogenous leukemia cells. Cancer Res. 68 9394 PMID: 19010914
Keywords: Perifosine, supplier, PKB, Akt, inhibitors, inhibts, lipid, rafts, MAPK, autophagy, apoptosis, induces, inducers, Kv2.1, antitumor, orally, bioavailable, inward, rectifier, potassium, current, KRX-0401, Akt, (Protein, Kinase, B), Protein, Kinase, B/Akt, Autophagy, Voltage-Gated, Potassium, Channels, Akt, (Protein, Kinase, B), Tocris Bioscience
