Biological Activity
Selective GABAB antagonist. Phosphono analog of GABAB agonist baclofen (Cat. No. 0417).
Technical Data
| M. Wt | 249.63 |
| Formula | C9H13ClNO3P |
| Storage | Store at RT |
| Purity | ≥97% (HPLC) |
| CAS Number | 114012-12-3 |
| PubChem ID | 1641 |
| InChI Key | VSGNGLJPOGUDON-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(CN)CP(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. NaOH | 6.24 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 249.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.01 mL | 20.03 mL | 40.06 mL |
| 5 mM | 0.8 mL | 4.01 mL | 8.01 mL |
| 10 mM | 0.4 mL | 2 mL | 4.01 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hasuo and Gallagher (1988) Comparison of antagonism by phaclofen of baclofen induced hyperpolarization and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. Neurosci.Lett. 86 77 PMID: 3362432
Karlsson et al (1988) Phaclofen: a GABAB blocker reduced long-duration inhibition in the neocortex. Eur.J.Pharmacol. 148 485 PMID: 2838310
Kerr et al (1987) Phaclofen: a peripheral and central baclofen antagonist. Brain Res. 405 150 PMID: 3032346
Keywords: Phaclofen, supplier, selective, GABAB, antagonists, Receptors, GABAB, Receptors, GABAB, Receptors, Tocris Bioscience
