Biological Activity
Selective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model.
Technical Data
| M. Wt | 194.23 |
| Formula | C14H10O |
| Storage | Store at +4°C |
| CAS Number | 484-17-3 |
| PubChem ID | 10229 |
| InChI Key | DZKIUEHLEXLYKM-UHFFFAOYSA-N |
| Smiles | OC2=CC1=C(C3=C2C=CC=C3)C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.42 | 100 | |
| ethanol | 19.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 194.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.15 mL | 25.74 mL | 51.49 mL |
| 5 mM | 1.03 mL | 5.15 mL | 10.3 mL |
| 10 mM | 0.51 mL | 2.57 mL | 5.15 mL |
| 50 mM | 0.1 mL | 0.51 mL | 1.03 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Simard et al (2012) Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle. Br.J.Pharmacol. 165 2354 PMID: 22014185
Grand et al (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br.J.Pharmacol. 153 1697 PMID: 18297105
Keywords: 9-Phenanthrol, supplier, Transient, receptor, potential, TRPM4, blockers, TRP, channels, arrhythmias, cardiac, heart, anti-arrhythmic, depolarisations, TRPM, TRPM, Tocris Bioscience
