BiologicalActivity
Glucokinasepartialactivator(EC50=174nM).Enhancesglucose-stimulatedinsulinsecretioninisletcellculturesandtranslocationofglucokinasefromthenucleustothecytoplasminhepatocytesinvitro.Reducespost-prandialplasmaglucoselevelsinanoralglucosetolerancetestinrats.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
PF04937319isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 432.43 |
| Formula | C22H20N6O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1245603-92-2 |
| PubChemID | 46916694 |
| InChIKey | MASKQITXHVYVFL-UHFFFAOYSA-N |
| Smiles | CC1=CC2=C(OC3=CN=C(C(N(C)C)=O)N=C3)C=C(C(NC4=CN=C(C)C=N4)=O)C=C2O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight432.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.31mL | 11.56mL | 23.13mL |
| 5mM | 0.46mL | 2.31mL | 4.63mL |
| 10mM | 0.23mL | 1.16mL | 2.31mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |
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