Biological Activity
α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.
Technical Data
| M. Wt | 203.67 |
| Formula | C9H13NO2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 61-76-7 |
| PubChem ID | 441279 |
| InChI Key | OCYSGIYOVXAGKQ-FVGYRXGTSA-N |
| Smiles | OC1=CC=CC([C@@H](O)CNC)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.37 | 100 | |
| water | 20.37 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 203.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.91 mL | 24.55 mL | 49.1 mL |
| 5 mM | 0.98 mL | 4.91 mL | 9.82 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Minneman et al (1994) Selectivity of agonists for cloned α1-adrenergic receptor subtypes. Mol.Pharmacol. 46 929 PMID: 7969082
Ford et al (1997) Pharmacological pleiotropism of the human recombinant α1A-adrenoceptor: implications for α1-adrenoceptor classification. Br.J.Pharmacol. 121 1127 PMID: 9249248
Morton et al (2007) α1A-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br.J.Pharmacol. 150 112 PMID: 17115072
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