Tocris/picropodophophylotoxin/2956/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/picropodophophylotoxin/2956/10/10 mg

Tocris/picropodophophylotoxin/2956/10/10 mg

商品编号： 2956/10

品牌： Tocris Bioscience

市场价： ¥3980.00

美元价： 2388.00

产地：美国(厂家直采)

公司：

产品分类：激酶

公司分类： kinase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectiveIGF1Rinhibitor

AlternativeNames:Picropodophyllin

ChemicalName:(5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Orallyactiveinsulin-likegrowthfactor1receptor(IGF1R)inhibitorthatexhibitsnoactivityattheinsulinreceptor,FGFR,PDGFRorEGFR.InhibitsIGF1Rautophosphorylation(IC₅₀~1nM),increasesthefractionofcellsintheG₂/Mphaseandupregulatesapoptosis.Exhibitsantiproliferativeeffectsinmultiplecancercelllines(IC₅₀=0.05-15μM),andhasanticancerandantineovascularizationactivityinvivo.

TechnicalData

M.Wt	414.41
Formula	C₂₂H₂₂O₈
Storage	Storeat+4°C
Purity	≥97%(HPLC)
CASNumber	477-47-4
PubChemID	72435
InChIKey	YJGVMLPVUAXIQN-HAEOHBJNSA-N
Smiles	O=C3OC[C@]([C@@]([H])3[C@@H]4[C@]5=CC(OC)=C(OC)C(OC)=C5)([H])[C@@H](O)C1=C4C=C(OCO2)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	41.44	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight414.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.41mL	12.07mL	24.13mL
5mM	0.48mL	2.41mL	4.83mL
10mM	0.24mL	1.21mL	2.41mL
50mM	0.05mL	0.24mL	0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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