BiologicalActivity
Inhibitsp53bindingtomitochondriabyreducingitsaffinityforantiapoptoticproteinsBcl-2andBcl-XL.Displaysnoeffectonthetransactivationalorcellcyclecheckpointcontrolfunctionofp53.Potentiallyincreasesreprogrammingefficiencyofhumansomaticcellstoinducedpluripotentstemcells(iPSCs)bysilencingp53.Reducescelldeathinducedbyγ-rADIationinvitroandprotectsmicefromdosesofradiationthatcauselethalhematopoieticsyndrome.Selectivelyinhibitsheatshockprotein70(HSP70)activity.
CompoundLibraries
Pifithrin-μisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 181.21 |
| Formula | C8H7NO2S |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 64984-31-2 |
| PubChemID | 327653 |
| InChIKey | ZZUZYEMRHCMVTB-UHFFFAOYSA-N |
| Smiles | NS(=O)(=O)C#CC1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.12 | 100 | |
| ethanol | 13.12 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight181.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.52mL | 27.59mL | 55.18mL |
| 5mM | 1.1mL | 5.52mL | 11.04mL |
| 10mM | 0.55mL | 2.76mL | 5.52mL |
| 50mM | 0.11mL | 0.55mL | 1.1mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
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