Biological Activity
Muscarinic agonist.
Compound Libraries
Pilocarpine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 244.72 |
| Formula | C11H16N2O2.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 54-71-7 |
| PubChem ID | 5909 |
| InChI Key | RNAICSBVACLLGM-GNAZCLTHSA-N |
| Smiles | O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.35 | 75 | |
| water | 24.47 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 244.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.09 mL | 20.43 mL | 40.86 mL |
| 5 mM | 0.82 mL | 4.09 mL | 8.17 mL |
| 10 mM | 0.41 mL | 2.04 mL | 4.09 mL |
| 50 mM | 0.08 mL | 0.41 mL | 0.82 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
ten Berge et al (1996) Differences in the prejunctional effects of methacholine and pilocarpine on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 354 606 PMID: 8938659
Wang et al (1999) Pilocarpine modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current. Br.J.Pharmacol. 126 1725 PMID: 10372814
Brown and Taylor (1996) Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo Chapter 7, p147 PMID:
Merck Index 12 7578 PMID:
Keywords: Pilocarpine hydrochloride, supplier, Muscarinic, agonists, Receptors, Acetylcholine, ACh, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience
