Biological Activity
Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
Compound Libraries
Pioglitazone hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 392.9 |
| Formula | C19H20N2O3S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 112529-15-4 |
| PubChem ID | 60560 |
| InChI Key | GHUUBYQTCDQWRA-UHFFFAOYSA-N |
| Smiles | O=C(S3)NC(C3CC(C=C2)=CC=C2OCCC1=NC=C(CC)C=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.82 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 392.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.73 mL | 25.45 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.09 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665 PMID: 8576907
Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704 PMID: 11095972
Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13 PMID: 11594239
Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518 PMID: 11906293
Keywords: Pioglitazone hydrochloride, supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, PPARgamma, Receptors, PPARgamma, Receptors, Tocris Bioscience
