Biological Activity
Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.
Technical Data
| M. Wt | 185.23 |
| Formula | C12H11NO |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 53179-13-8 |
| PubChem ID | 40632 |
| InChI Key | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| Smiles | CC1=CN(C(=O)C=C1)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 18.52 | 100 | |
| water | 3.7 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 185.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.4 mL | 26.99 mL | 53.99 mL |
| 5 mM | 1.08 mL | 5.4 mL | 10.8 mL |
| 10 mM | 0.54 mL | 2.7 mL | 5.4 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.08 mL |
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References
References are publications that support the products' biological activity.
Iyer et al (1999) Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 289 211 PMID: 10087006
Kehrer and Margolin (1997) Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 90 125 PMID: 9067480
Mei et al (2005) Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 313 379 PMID: 15608079
Oku et al (2002) Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 446 167 PMID: 12098599
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