Biological Activity
A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors.
Technical Data
| M. Wt | 371.27 |
| Formula | C16H18N4O2.2HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1451048-94-4 |
| PubChem ID | 3038520 |
| InChI Key | VRSRBPOCDOKYKT-UHFFFAOYSA-N |
| Smiles | Cl.Cl.C(N1CCN(CC1)C1=NC=CC=N1)C1=CC=C2OCOC2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 8.37 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 371.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.47 mL | 26.93 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
| 10 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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References
References are publications that support the products' biological activity.
Cagnotto et al (1996) In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. Eur.J.Pharmacol. 313 63 PMID: 8905329
Jenne (1992) Parkinson's disease: pathological mechanisms and actions of piribedil. J.Neurol. 239 S2 PMID: 1634907
Offermeier and van Rooyen (1986) A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S36080). Life Sci. 38 895 PMID: 3081774
Merck Index 12 7648 PMID:
Keywords: Piribedil dihydrochloride, supplier, Dopamine, agonist, D2-like, Non-Selective, Receptors, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience
