Biological Activity
Anti-inflammatory; highly selective inhibitor of COX-1 (ratio of IC50 values for COX-2/COX-1 ~ 600).
Technical Data
| M. Wt | 331.35 |
| Formula | C15H13N3O4S |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 36322-90-4 |
| PubChem ID | 54676228 |
| InChI Key | QYSPLQLAKJAUJT-UHFFFAOYSA-N |
| Smiles | CN1C(C(=O)NC2=CC=CC=N2)=C(O)C2=C(C=CC=C2)S1(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 331.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.09 mL | 30.18 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Mitchell et al (1995) Cyclooxygenase-2. Regulation and relevance in inflammation. Biochem.Pharmacol. 50 1535 PMID: 7503754
Merck Index 12 7661 PMID:
Keywords: Piroxicam, supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, COX, Oxygenases, Oxidases, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience
