Biological Activity
Synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.
Compound Libraries
Pitavastatin calcium is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 440.5 |
| Formula | C25H23FNO4.0.5Ca |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 147526-32-7 |
| PubChem ID | 5282451 |
| InChI Key | RHGYHLPFVJEAOC-FFNUKLMVSA-L |
| Smiles | [Ca++].O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)C=CC1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.05 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 440.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.7 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Saka et al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770 PMID: 16810078
Mukhtar et al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239 PMID: 15854203
Aoki et al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904 PMID: 9296275
Keywords: Pitavastatin calcium, supplier, NK-104, HMG, CoA, reductase, inhibitors, inhibits, synthetic, statins, NK-104, HMG-CoA, Reductase, HMG-CoA, Reductase, Tocris Bioscience
