托克里斯/普莱迪诺利B/6070/500U/500微克-免疫在线蚂蚁淘旗下平台

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商品详细托克里斯/普莱迪诺利B/6070/500U/500微克

托克里斯/普莱迪诺利B/6070/500U/500微克

商品编号： 6070/500U

品牌： Tocris Bioscience

市场价： ¥6580.00

美元价： 3948.00

产地：美国(厂家直采)

公司：

产品分类：合成

公司分类： Synthesis

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:mRNAsplicinginhibitor;antitumor

ChemicalName:(4R,7R,8S,9E,11S,12S)-8-(Acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-hexADIen-1-yl]-7,11-dimethyloxacyclododec-9-en-2-one

Purity:≥95%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

mRNAsplicinginhibitor;decreasessplicingcapacityupto75%invitro.Directlytargetssplicesome-associated130(SAP130),inhibitssplicingfactor3Bsubunit(SF3B1)andimpairsU2smallnuclearribonucleoprotein(U2snRNP)interactionwithpre-mRNA.ArrestscellcycleinG₁andG_2/Mphases.Displaysantitumoractivityagainstgastriccancercells(IC₅₀valuesare1.6-4.9nM).Cellpermeableandactiveinvivo.

TechnicalData

M.Wt	536.7
Formula	C₃₀H₄₈O₈
Storage	Storeat-20°C
Purity	≥95%(HPLC)
CASNumber	445493-23-2
PubChemID	90909513
InChIKey	SDOUORKJIJYJNW-UHFFFAOYSA-N
Smiles	C[C@@H](/C=C/[C@H](OC(C)=O)[C@](C)(O)CC[C@@H](O)C1)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@@H]([C@H](C)[C@@H](O)CC)O2)OC1=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	1	2

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight536.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.86mL	9.32mL	18.63mL
5mM	0.37mL	1.86mL	3.73mL
10mM	0.19mL	0.93mL	1.86mL
50mM	0.04mL	0.19mL	0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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