Biological Activity
Stearoyl-CoA desaturase 1 (SCD1) inhibitor. Used to selectively eliminate undifferentiated human pluripotent stem cells (hPSCs) from culture; induces ER stress, attenuates protein synthesis and induces apoptosis in hPSCs. Prevents teratoma formation in immunocompromised mice.
Compound Libraries
PluriSln 1 is also offered as part of the Tocriscreen Plus and Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 213.24 |
| Formula | C12H11N3O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 91396-88-2 |
| PubChem ID | 225362 |
| InChI Key | HUDWXDLBWRHCKO-UHFFFAOYSA-N |
| Smiles | O=C(NNC2=CC=CC=C2)C1=CC=NC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.32 | 100 | |
| ethanol | 21.32 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 213.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.69 mL | 23.45 mL | 46.9 mL |
| 5 mM | 0.94 mL | 4.69 mL | 9.38 mL |
| 10 mM | 0.47 mL | 2.34 mL | 4.69 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Ben-David et al (2013) Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell 12 167 PMID: 23318055
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