Biological Activity
TRPA1 channel activator (EC50 = 400 nM) that is selective against TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8 channels. Acts as an analgesic via desensitization of sensory neurons. Also exhibits antifungal activity via inhibition of mitochondrial ATPase.
Technical Data
| M. Wt | 234.33 |
| Formula | C15H22O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 6754-20-7 |
| PubChem ID | 72503 |
| InChI Key | AZJUJOFIHHNCSV-KCQAQPDRSA-N |
| Smiles | [H][C@]12C(C)(C)CCC[C@@](C)1[C@@H](C=O)C(C=O)=CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.43 | 100 | |
| ethanol | 23.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 234.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.27 mL | 21.34 mL | 42.67 mL |
| 5 mM | 0.85 mL | 4.27 mL | 8.53 mL |
| 10 mM | 0.43 mL | 2.13 mL | 4.27 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.85 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lunde and Kubo (2000) Effect of polygodial on the mitochondrial ATPase of Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 44 1943 PMID: 10858359
Escalera et al (2008) TRPA1 mediates the noxious effects of natural sesquiterpene deterrents. J.Biol.Chem. 283 24136 PMID: 18550530
Matsuda et al (2002) Protective effect of polygodial and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg.Med.Chem.Letts. 12 477 PMID:
Keywords: Polygodial, supplier, TRPA1, channel, activator, mitochondrial, ATPase, antifungal, inhibits, mitochondrial, ATPase, TRPA1, Other, ATPases, TRPA1, Tocris Bioscience
