Biological Activity
α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.
Compound Libraries
Prazosin hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 419.87 |
| Formula | C19H21N5O4.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 19237-84-4 |
| PubChem ID | 68546 |
| InChI Key | WFXFYZULCQKPIP-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC2=NC(=NC(N)=C2C=C1OC)N1CCN(CC1)C(=O)C1=CC=CO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 25 mM in DMSO and to 5 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 419.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.91 mL | 23.82 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Mathe et al (1996) Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens. Eur.J.Pharmacol. 309 1 PMID: 8864686
Paul et al (1999) Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 290 334 PMID: 10381796
Pickering and Niles (1990) Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 175 71 PMID: 2157597
Merck Index 12 7897 PMID:
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