Biological Activity
GABAA receptor positive allosteric modulator. Neuroactive steroid.
Compound Libraries
Pregnanolone is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 318.49 |
| Formula | C21H34O2 |
| Storage | Store at RT |
| CAS Number | 128-20-1 |
| PubChem ID | 31402 |
| InChI Key | AURFZBICLPNKBZ-YZRLXODZSA-N |
| Smiles | C[C@@]12[C@@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@](C)=O)([H])C[C@H](O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.85 | 100 | |
| ethanol | 31.85 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 318.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.7 mL | 31.4 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Harrison et al (1987) Structure-activity relationships for steroid interaction with the γ-aminobutyric acidA receptor complex. J.Pharmacol.Exp.Ther. 241 346 PMID: 3033209
Morris et al (1999) Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids. Mol.Pharmacol. 56 752 PMID: 10496958
Keywords: Pregnanolone, supplier, GABAA, receptors, positive, allosteric, modulators, neuroactive, steroid, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
