Biological Activity
Prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.
Technical Data
| M. Wt | 1912.26 |
| Formula | C80H138N26O24S2 |
| Sequence | KTNMKHMAGAAAAGAVVGGLG |
| Storage | Desiccate at -20°C |
| CAS Number | 148439-49-0 |
| PubChem ID | 16135249 |
| InChI Key | XPZWWTIIKSODDO-MBNDGZRNSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1912.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.52 mL | 2.61 mL | 5.23 mL |
| 5 mM | 0.1 mL | 0.52 mL | 1.05 mL |
| 10 mM | 0.05 mL | 0.26 mL | 0.52 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Forloni et al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543 PMID: 8464494
Pietri et al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470 PMID: 16864581
Bai et al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9 PMID: 18602709
Keywords: Prion Protein 106-126 (human), supplier, Prion, protein, fragment, PrPSc, Antiprion, Neuronal, Metabolism, Neuronal, Metabolism, Neuronal, Metabolism, Tocris Bioscience
