Biological Activity
Inhibitor of multidrug resistance-associated proteins (MRP). Inhibits organic acid transport in the kidney and other organs. Also exhibits inhibitory activity against pannexin 1 channels (IC50 ~ 150 μM).
Compound Libraries
Probenecid is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 285.36 |
| Formula | C13H19NO4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 57-66-9 |
| PubChem ID | 4911 |
| InChI Key | DBABZHXKTCFAPX-UHFFFAOYSA-N |
| Smiles | O=S(C1=CC=C(C(O)=O)C=C1)(N(CCC)CCC)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.54 | 100 | |
| ethanol | 28.54 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 285.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.5 mL | 17.52 mL | 35.04 mL |
| 5 mM | 0.7 mL | 3.5 mL | 7.01 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.5 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cunningham et al (1981) Clinical pharmacokinetics of probenecid. Clin.Pharmacokinet. 6 135 PMID: 7011657
Hammond et al (2007) Glutathione export during apoptosis requires functional multidrug resistance-associated proteins. J.Biol.Chem. 282 14337 PMID: 17374608
Silverman et al (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am.J.Physiol.Cell Physiol. 295 C761 PMID: 18596212
Ishikawa et al (2010) Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol.Pharm.Bull. 33 504 PMID: 20190417
Keywords: Probenecid, supplier, ATP-binding, cassette, ABC, multidrug, resistance-associated, proteins, MRP, inhibitors, inhibits, Multidrug, Transporters, Multidrug, Transporters, Tocris Bioscience
