Biological Activity
Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally active.
Technical Data
| M. Wt | 356.39 |
| Formula | C18H25N2NaO4 |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 99247-33-3 |
| PubChem ID | 23677833 |
| InChI Key | UFMWGCINVOIJSO-UHFFFAOYSA-M |
| Smiles | [Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.64 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 356.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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References
References are publications that support the products' biological activity.
Iwamoto et al (1984) In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini. Gastroenterol.Jpn. 19 53 PMID: 6202584
Mauss et al (1994) Effects of gastrin, proglumide, loxiglumide and L-365,260 on growth of human colon carcinoma cells. Anticancer Res. 14 215 PMID: 8166452
Hahne et al (1981) Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc.Natl.Acad.Sci.U.S.A. 78 6304 PMID: 6171817
Keywords: Proglumide sodium salt, supplier, cholecystokinin, antagonists, non, selective, milid, orally, active, available, Non-selective, CCK, Non-selective, CCK, Tocris Bioscience
